Jarrow Formulas Natural Source Pterostilbene, Supports Cardiovascular and Neurologic Health, 50 Mg, 60 Veggie Caps

Product Profile Pterostilbene (terro-STILL-bean) is found naturally in blueberries, grapes, and in the bark of the Indian Kino Tree (Pterocarpus marsupium). The name Pterocarpus derives from ancient Greek and means “wing fruit”, referring to the shape of the seedpods in this genus. Preparations of the Indian Kino Tree have been used in Ayurvedic medicine for centuries in relation to inflammation and blood-sugar balance. Similarly, resveratrol, a structural cousin of pterostilbene, has been touted for effects related to the heart.* Pterostilbene vs. Resveratrol Pterostilbene has been shown to have the same antioxidant potential as resveratrol in a standard assay of antioxidant potential (Trolox). However, the two methylated hydroxyl groups make pterostilbene more lipophilic and less susceptible to conjugation-induced degradation; this leads to a greater half-life in the body compared to resveratrol (105 vs. 14 minutes). These specific structural differences seem to make resveratrol more adept at combating reactive oxygen species (ROS) in whole blood and lymphocytes and pterostilbene better at targeting extracellelular ROS.* Such extracellular ROS are often responsible for tissue damage with imbalanced inflammatory response, amongst other things. As such, pterostilbene and resveratrol tend to be more complementary in their action than competitive. Work in animals has even suggested synergies between the two, along with quercetin. This is one reason both are included, along with quercetin and other components found in grapes, in a related Jarrow Formulas product: Resveratrol Synergy. Distinguishing Features: 99% pure dimethylresveratrol 50 mg pterostilbene per serving Matters Of The Heart* Reduced oxidative stress and a properly modulated inflammatory response seem to be at the root of enduring health, particularly cardiovascular health. In vitro and animal studies suggest pterostilbene has positive effects on multiple inflammation-related biomarkers.* But as we know, a healthy heart and network of blood vessels also involves balanced levels of blood lipids and blood sugar. It’s understood that chronically high plasma levels of glucose lead to advanced glycation end products (AGE), which in turn cause the deterioration of bodily tissues, and an increased risk of developing insulin resistance. Pterostilbene seems to offer some protec